Neurotensin-induced tumor formation is regulated by micro rna 133a-aftiphilin-dependent receptor recycling
AssigneeThe Regents of the University of California
InventorsCharalabos POTHOULAKIS, Dimitrios ILIOPOULOS, Ka Man LAW
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Abstract
This application discloses methods of treating, preventing, and diagnosing colorectal cancer and IBD in a subject comprising administering an effective dose of antisense miR-133α or AFTPH to the subject or detecting expression levels of miR-133α and AFTPH.
Claims27
A method of treating colorectal cancer or inflammatory bowel disease in a subject, the treatment comprising administering an effective dose of antisense miR-133α.
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A method of diagnosing colorectal cancer or inflammatory bowel disease in a subject wherein an increased expression of miR-133α is detected, wherein the increased expression of miR-133α compared to a control subject is indicative of the presence of colorectal cancer or inflammatory bowel disease or the likelihood of the colorectal cancer or inflammatory bowel disease progressing.
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A method of treating colorectal cancer or inflammato bowe disease in a subject, the treatment comprising administering an effective dose of a AFTPH polypeptide.
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A method of diagnosing colorectal cancer or inflammatory bowel disease in a subject wherein a decreased expression of AFTPH is detected, wherein the decreased expression of AFTPH compared to a control subject is indicative of the presence of colorectal cancer or inflammatory bowel disease or the likelihood of the colorectal cancer or inflammatory bowel disease progressing.
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Dependencies are inferred from the claim text.