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US 2016/0102354 A1Published application
Systems For Biomarker Detection
AssigneeAdvanced Genomic Technology, LLC
InventorEugenia Wang
Life of this patent
Estimating the term…
Abstract
Biomarker associated with Alzheimer's Disease (AD) and/or Mild Cognitive Impairment (MCI), where the biomarker is an intracellular or circulating microRNA and/or target protein thereof, and use thereof in methods for determining, diagnosing, monitoring AD, mild AD, moderate Ad, severe AD, MCI, early MCI, late MCI, and the like, as well as in methods for selecting candidate therapeutic compounds for treating same.
Claims21
1-3. (canceled)
A system, comprising:
- a. a reverse transcription real time polymerase chain reaction (RT-qPCR) apparatus for processing a substantially cell free fluid sample from a test subject to obtain an amplification of a predefined circulating microRNA selected from the group consisting of miR-34a, miR-34c, miR-181b, and any combinations thereof, wherein said RT-qPCR apparatus is configured for generating a signal indicative of the amplification of the predefined circulating microRNA;
- and
- b. an apparatus having an input in communication with said RT-qPCR apparatus for receiving said signal;
- a processing unit;
- a memory;
- and an output;
- said processing unit being programmed for:
- i. processing the signal to derive a level of the predefined circulating microRNA in the sample;
- ii. comparing the level of the predefined circulating microRNA in the sample to at least one reference level of microRNA stored in the memory, the at least one reference level of microRNA being associated with an Alzheimer's Disease (AD) status of at least one reference subject;
- iii. causing an output signal to be released via the output, the output signal being indicative of an AD status of the test subject based on an outcome of said comparison.
7 more elements
Dependencies are inferred from the claim text.