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US 2016/0102310 A1Published application
miR-96-5p INHIBITOR AND A SCREENING METHOD FOR THE INHIBITOR
AssigneeTeikyo University
InventorsToshio NAKAKI, Chisato KINOSHITA
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Abstract
The present invention provides novel medical means to facilitate glutathione (GSH) synthesis in the brain. These means are miR-96-5p inhibitor increasing GSH expression in the brain and a pharmaceutical composition comprising the miR-96-5p inhibitor and having a preventive and/or therapeutic performance to a disease caused by decrease of GSH amount or depression of GSH activity.
Claims11
A miRNA-96-5p inhibitor increasing an expression of glutathione (GSH) in the brain.
A screening method for a substance inhibiting an activity of miRNA-96-5p, which comprises:
- (a) identifying a candidate substance capable of binding with miRNA-96-5p;
- (b) contacting the candidate substance with a cell expressing excitatory amino acid carrier 1 (EAAC1) and miRNA-96-5p;
- and
- (c) measuring expression level at least one of glutathione and EAAC1, and deciding the candidate substance of which measurement in (c) is increased compared with a control measurement as a target substance.
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Dependencies are inferred from the claim text.