Compositions and methods for the treatment of ocular oxidative stress and retinitis pigmentosa
AssigneeThe Johns Hopkins University
InventorPeter A. Campochiaro
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Abstract
Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including age-related macular degeneration and retinitis pigmentosa. Oral antioxidants may provide modest benefits, but more efficient ways of preventing oxidative damage are needed. Compositions and methods are provided herein for the prevention, amelioration, and/or treatment of early or late stage ocular disease by increasing the expression or activity of one or more peroxidases in cells of the eye, particularly retinal cells, and further optionally increasing the expression or activity of one or more superoxide dismuatases in the same cells.
Claims24
A method for the prevention, amelioration, or treatment of a disease or condition associated with oxidative stress in a subject comprising administration of a therapeutically effective amount of a compound to the subject to increase the expression or activity of a at least an active fragment of a peroxidase in the subject.
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A composition comprising a compound to increase the expression or activity of a at least an active peroxide metabolizing fragment of a peroxide metabolizing enzyme in a cell.
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Dependencies are inferred from the claim text.