Modified adenovirus hexon protein and uses thereof

A self-priming immunogenic composition comprising a pharmaceutically acceptable carrier and

• an adenovirus having a capsid comprising a modified adenovirus hexon protein, said modified adenovirus hexon protein comprising hypervariable region 1 which has a deletion consisting of at least twenty-five consecutive amino acids and an exogenous amino acid sequence consisting of 5 to 45 amino acids in length inserted in the site of the hypervariable region 1 deletion, with the proviso that said exogenous amino acid sequence is other than an adenovirus sequence,
• wherein said exogenous amino acid sequence is a first immunogenic amino acid sequence;
• wherein said adenovirus further comprises a nucleic acid sequence encoding a second immunogenic amino acid sequence under control of sequences which direct expression thereof in a host cell.

(canceled)

A self-priming immunogenic composition comprising:

• an adenovirus having a capsid comprising a modified adenovirus hexon protein, said modified adenovirus hexon protein comprising hypervariable region 4 which has a deletion of at least about twenty-five consecutive amino acids and an exogenous amino acid sequence consisting of about 5 to about 45 amino acids in length inserted in the site of the hypervariable region 4 deletion, with the proviso that said exogenous amino acid sequence is other than an adenovirus sequence,
• wherein said exogenous amino acid sequence is a first immunogenic amino acid sequence;
• wherein said adenovirus further comprises a nucleic acid sequence encoding a second immunogenic amino acid sequence under control of sequences which direct expression thereof in a host cell.