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AssigneeAcademia Sinica
InventorsChi-Huey WONG, Tsui-Ling HSU, Yi-Wei LOU, Chih-Wei LIN, Shih-Chi YEH, Chung-Yi WU, Han-Chung WU
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Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.
An isolated humanized monoclonal glycoantibody that specifically binds to Neu5Acα2→3Galβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1.
An isolated humanized monoclonal antibody that specifically binds to Neu5Acα2→3Galβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1, Neu5Acα2→3Galβ1→3GalNAcβ1→3Galα1, Fucα1→2Galβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1, Galβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1, GalNAcβ1→3Galα1→4Galβ1→4Glcβ1 and Neu5Acα2-8→Neu5Acα2→3Galβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1.
A method for detecting cancer in a subject, comprising:
An isolated antibody or an antigen binding fragment thereof, wherein the antibody comprises a N-glycan attached to the Asn-297 of the Fc region of said antibody wherein the N-glycan consists of the structure of Sia2(α2-6)Gal2GlcNAc2Man3GlcNAc2 and wherein the antibody specifically binds to at least one antigen associated with cancers selected from the group consisting of Globo-H, SSEA-3, and SSEA-4.
An isolated humanized monoclonal glycoantibody that specifically binds to Neu5Acα2→3Galβ1→3GalNAcβ1→3Galα1→4Galβ1→4Glcβ1, and oxidized variants thereof, and conjugation products to said oxidized variants.
Dependencies are inferred from the claim text.