Antibodies Targeting M-CSF
AssigneeMorphosys AG
InventorsFrancis Dodeller, Robert Rauchenberger
Life of this patent
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Abstract
This disclosure generally relates to antibodies or antibody fragments which specifically bind to M-CSF. In particular antibodies and antibody fragments are disclosed which bind to M-CSF and which inhibit binding of M-CSF to the M-CSF receptor with an IC50 of 10 pM or less. The invention also relates to nucleic acids, vectors and host cells capable of expressing the antibodies or fragments thereof of the invention, pharmaceutical compositions comprising the antibodies or fragments thereof and uses of said antibodies or fragments thereof and compositions for treatment of specific diseases.
Claims15
An isolated antibody or antibody fragment, which specifically binds to M-CSF and wherein said isolated antibody or antibody fragment is able to inhibit the binding of M-CSF to the M-CSF receptor with an IC50 of 10 pM or less in a receptor binding inhibition assay comprising M-CSF at a final concentration of 12.5 pM.
Dependencies are inferred from the claim text.