Methods and compositions for treating brain diseases
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorMichael SIERKS
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Abstract
The present invention provides methods of delivering a protein to the brain of a mammal, comprising administering to the mammal a therapeutic fusion protein comprising a homeodomain peptide operably linked to a therapeutic agent.
Claims26
A method of delivering a protein to the brain of a mammal, comprising administering to the mammal
- (a) a therapeutic fusion protein comprising a homeodomain peptide tag operably linked to a therapeutic agent or
- (b) a viral vector comprising a nucleic acid sequence encoding a homeodomain peptide tag operably linked to a therapeutic agent,
- wherein the homeodomain peptide tag is 15-35 amino acids in length, has at least 80% identity to SEQ ID NO:5 or SEQ ID NO:6, has cellular penetration and secretion functions, and facilitates blood-brain barrier transport of a therapeutic agent in the mammal.
7-13. (canceled)
(canceled)
A fusion protein comprising a homeodomain peptide tag that facilitates transport of a therapeutic antibody fragment across a blood-brain barrier operably linked to a therapeutic antibody fragment, wherein the homeodomain peptide tag is 15-35 amino acids in length, has at least 80% identity to SEQ ID NO:5 or SEQ ID NO:6, and has cellular penetration and secretion functions.
A viral vector comprising a nucleic acid sequence encoding a homeodomain peptide tag operably linked to a therapeutic agent.
(canceled)
32-34. (canceled)
Dependencies are inferred from the claim text.