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US 2016/0102137 A1Published application
Crosslinked anti-hiv-1 compositions for potent and broad neutralization
OwnerPamela J. Bjorkman, Rachel P. Galimidi +2inventors
InventorsPamela J. Bjorkman, Rachel P. Galimidi, Anthony P. West, Michel C. Nussenzweig
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Abstract
An anti-HIV-1 spike composition includes a first anti-HIV-1 antibody Fab and a second anti-HIV-1 antibody Fab linked by a DNA or protein linker molecule to form a crosslinked homo-diFab or hetero-diFab having improved viral potency and neutralization. The anti-HIV-1 antibody Fabs include anti-gp120 CD4, anti-gp120 V1V2, anti-gp120 V3, and anti-gp41.
Claims20
A composition comprising:
- a first anti-HIV-1 antibody Fab;
- a second anti-HIV-1 antibody Fab;
- and
- a linker molecule conjugated between the C-terminus of the first anti-HIV-1 antibody Fab and the C-terminus of the second anti-HIV-1 antibody Fab.
1 more element
Dependencies are inferred from the claim text.