HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS

A method for augmenting an immunogenicity of an antigen in a subject in need thereof, comprising co-administering a pharmaceutically effective amount of said antigen with an adjuvant composition comprising a GSLs compound of the general Formula I:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R1 is —OH or halogen;
• R2 is hydrogen or halogen;
• R3 is —OH, hydrogen or halogen;
• each instance of R4 and R5 is independently selected from the group consisting of hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted alkoxy, an optionally substituted amino group, and optionally substituted acyl;
• n is an integer of 1 to 15, inclusive;
• m is an integer of 1 to 20, inclusive;
• with the proviso that the compound is not any one of C34, II-1 to 11-12, III-1 to III-24, 43, and 53.