Bace1 inhibitors

A compound of formula I:

• wherein:
• n is 1, 2 or 3;
• R1 is selected from the group consisting of
• i) C1-6-alkyl and
• ii) halogen-C1-6-alkyl;
• R2 is selected from the group consisting of
• i) C1-6-alkyl, and
• ii) halogen-C1-6-alkyl;
• or R1 and R2 form together with the C-atom they are attached to, a C3-6-cycloalkyl-, wherein the C3-6-cycloalkyl- is optionally substituted by one or more substituents selected from the group consisting of halogen and hydroxyl;
• R3 is each independently selected from the group consisting of
• i) hydrogen,
• ii) C1-6-alkyl, and
• iii) halogen;
• R4 is each independently selected from the group consisting of
• i) hydrogen,
• ii) C1-6-alkyl, and
• iii) halogen;
• or wherein R3 and R4 together are —(CH2)m—, wherein m is 2, 3, 4 or 5,
• R5 is hydrogen.
• R6 is selected from the group consisting of
• i) C1-6-alkyl, and
• ii) halogen-C1-6-alkyl;
• R7 is selected from the group consisting of
• i) hydrogen, and
• ii) halogen;
• R8 is selected from the group consisting of
• i) aryl,
• ii) aryl substituted by 1-4 substituents individually selected from amino, cyano, halogen, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C2-6-alkynyl-C1-6-alkoxy, C2-6-alkynyl, C1-6-alkyl, COOR9, wherein R9 is H or C1-6-alkyl, CONR10R11, wherein R10 is H or C1-6-alkyl C3-6-cycloalkyl and R11 is H or C1-6-alkyl, C3-6-cycloalkyl that is optionally substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy, C3-6-cycloalkyl-C1-6-alkoxy and C3-6-cycloalkyl-C1-6-alkoxy, wherein the cycloalkyl unit is substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy;
• iii) heteroaryl, and
• iv) heteroaryl substituted by 1-4 substituents individually selected from amino, cyano, halogen, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C2-6-alkynyl-C1-6-alkoxy, C2-6-alkynyl, C1-6-alkyl, COOR9, wherein R9 is H or C1-6-alkyl, CONR10R11, wherein R10 is H or C1-6-alkyl C3-6-cycloalkyl and R11 is H or C1-6-alkyl, C3-6-cycloalkyl that is optionally substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy, C3-6-cycloalkyl-C1-6-alkoxy and C3-6-cycloalkyl-C1-6-alkoxy, wherein the cycloalkyl unit is substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy;
• or pharmaceutically acceptable salts thereof.