Tricyclic heterocyclic compounds and jak inhibitors

A compound represented by the formula (Ib):

• [wherein the ring Ab is represented by the formula (IIb):
• (wherein T1b is CR4bR5b, C(═O), C(═S), C(═NR17b), a sulfur atom, S(═O) or S(═O)2, U1b is a nitrogen atom or CR6b, and W1b is a nitrogen atom or CR8b), the formula (IIIb):
• (wherein T2b is CR4b, U2b is a nitrogen atom or CR6b, and W2b is CR8bR9b, C(═O), C(═S), C(═NR17b), NR10b, an oxygen atom, a sulfur atom, S(═O) or S(═O)2 (provided that when U2b is CR6b, W2b is not C(═O))) or the formula (IVb):
• (wherein T3b is CR4bR5b, C(═O), C(═S), C(═NR17b), a sulfur atom, S(═O) or S(═O)2, U3b is CR6bR7b, C(═O), C(═S), C(═NR17b), NR10b, an oxygen atom, a sulfur atom, S(═O) or S(═O)2, and W3b is CR8bR9b, C(═O), C(═S), C(═NR17b), NR11b, an oxygen atom, a sulfur atom, S(═O) or S(═O)2 (provided that when T3b is CR4bR5b and U3b is CR6bR7b, W3b is not CR8bR9b)),
• Xb is a nitrogen atom or CR15b,
• Yb is CR16b,
• R1b is a hydrogen atom, a halogen atom, a C1-6 alkyl group or a C1-6 haloalkyl group,
• the ring Bb is a C3-11 cycloalkane, a C3-11 cycloalkene, a 3 to 11-membered non-aromatic heterocycle, a C6-14 aromatic carbocycle or a 5 to 10-membered aromatic heterocycle,
• L1b is a single bond, a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group (the C1-6 alkylene group, the C2-6 alkenylene group and the C2-6 alkynylene group are unsubstituted or substituted with one or more identical or different substituents independently selected from the group consisting of halogen atoms, hydroxy groups, amino groups, cyano groups and nitro groups),
• L2b is a single bond, a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group (the C1-6 alkylene group, the C2-6 alkenylene group and the C2-6 alkynylene group are unsubstituted or substituted with one or more identical or different substituents independently selected from the group consisting of halogen atoms, hydroxy groups, amino groups, cyano groups and nitro groups),
• L3b is a single bond or represented by any of the following formulae (Vb-1) to (Vb-20):
• (wherein E1b is an oxygen atom, a sulfur atom or NR18b),
• when L3b is a single bond, R2b is a hydrogen atom, a halogen atom, a C3-11 cycloalkyl group, a 3 to 14-membered non-aromatic heterocyclyl group, a C6-14 aryl group, a 5 to 10-membered aromatic heterocyclyl group, a 8 to 14-membered partially saturated aromatic cyclic group or a 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon group (the C3-11 cycloalkyl group, the 3 to 14-membered non-aromatic heterocyclyl group, the C6-14 aryl group, the 5 to 10-membered aromatic heterocyclyl group, the 8 to 14-membered partially saturated aromatic cyclic group and the 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V4b and the substituent set V9b),
• when L3b is not a single bond, R2b is a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group (the C1-6 alkyl group and the C2-6 alkenyl group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V6b and the substituent set V9b), a C3-11 cycloalkyl group, a 3 to 14-membered non-aromatic heterocyclyl group, a C6-14 aryl group, a 5 to 10-membered aromatic heterocyclyl group, a 8 to 14-membered partially saturated aromatic cyclic group or a 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon group (the C3-11 cycloalkyl group, the 3 to 14-membered non-aromatic heterocyclyl group, the C6-14 aryl group, the 5 to 10-membered aromatic heterocyclyl group, the 8 to 14-membered partially saturated aromatic cyclic group and the 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V4b and substituent set V9b),
• nb is 0, 1 or 2,
• R3b is a hydroxy group, an amino group, a carboxy group, a carbamoyl group, a sulfamoyl group, a phosphono group, a phosphonooxy group, a sulfo group, a sulfoxy group, a tetrazolyl group, a halogen atom, a cyano group, a nitro group, a C1-6 alkyl group, a C1-6 haloalkyl group, a C3-11 cycloalkyl group, a C2-6 alkenyl group, a C2-6 haloalkenyl group, a C1-6 alkoxy group, a C1-6 haloalkoxy group, a C1-6 alkylthio group, a C1-6 haloalkylthio group, a C1-6 alkylcarbonyl group, a C1-6 haloalkylcarbonyl group, a C1-6 alkylsulfonyl group, a C1-6 haloalkylsulfonyl group, a C1-6 alkoxycarbonyl group, a mono-C1-6 alkylamino group, a di-C1-6 alkylamino group, a mono-C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group or a C1-6 alkylcarbonylamino group (when nb is 2, R3b's may be identical or different),
• each of R4b, R5b, R6b, R7b, R8b and R9b is independently a hydrogen atom, a hydroxy group, an amino group, a carboxy group, a carbamoyl group, a tetrazolyl group, a halogen atom, a cyano group, a C1-6 alkyl group, a C2-6 alkenyl group, a C1-6 alkoxy group, a C1-6 alkylthio group, a C1-6 alkylcarbonyl group, a C1-6 alkylsulfonyl group, a mono-C1-6 alkylamino group, a di-C1-6 alkylamino group (the C1-6 alkyl group, the C2-6 alkenyl group, the C1-6 alkoxy group, the C1-6 alkylthio group, the C1-6 alkylcarbonyl group, the C1-6 alkylsulfonyl group, the mono-C1-6 alkylamino group and the di-C1-6 alkylamino group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b), a C1-6 alkoxycarbonyl group, a C3-11 cycloalkyl group, a 3 to 11-membered non-aromatic heterocyclyl group, a C6-14 aryl group or a 5 to 10-membered aromatic heterocyclyl group (the C3-11 cycloalkyl group, the 3 to 11-membered non-aromatic heterocyclyl group, the C6-14 aryl group and the 5 to 10-membered aromatic heterocyclyl group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V1b),
• each of R10b and R11b is independently a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C1-6 alkylcarbonyl group, a C1-6 alkylsulfonyl group, a C1-6 alkoxycarbonyl group, a mono-C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group (the C1-6 alkyl group, the C2-6 alkenyl group, the C1-6 alkylcarbonyl group, the C1-6 alkylsulfonyl group, the C1-6 alkoxycarbonyl group, the mono-C1-6 alkylaminocarbonyl group and the di-C1-6 alkylaminocarbonyl group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b), a C3-11 cycloalkyl group, a 3 to 11-membered non-aromatic heterocyclyl group, a C6-14 aryl group or a 5 to 10-membered aromatic heterocyclyl group (the C3-11 cycloalkyl group, the 3 to 11-membered non-aromatic heterocyclyl group, the C6-14 aryl group and the 5 to 10-membered aromatic heterocyclyl group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V1b),
• each of R12b, R13b and R14b is independently a hydrogen atom, a C1-6 alkyl group or a C1-6 haloalkyl group (the C1-6 alkyl group and the C1-6 haloalkyl group are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b, the substituent set V8b and the substituent set V9b),
• each of R15b and R16b is independently a hydrogen atom, a halogen atom, a cyano group, a carbamoyl group, a C1-6 alkyl group, a C1-6 haloalkyl group, a C3-11 cycloalkyl group, a C1-6 alkoxy group, a C1-6 haloalkoxy group, a C1-6 alkylthio group, a C1-6 alkylcarbonyl group, a C1-6 alkylsulfonyl group, a 3 to 11-membered non-aromatic heterocyclyl group, a C6-14 aryl group or a 5 to 10-membered aromatic heterocyclyl group,
• each of R17b and R18b is independently a hydrogen atom, a hydroxy group, a cyano group, a nitro group, a C1-6 alkyl group or a C1-6 alkoxy group,
• the substituent set V1b consists of hydroxy groups, amino groups, carboxy groups, carbamoyl groups, sulfamoyl groups, phosphono groups, phosphonooxy groups, sulfo groups, sulfoxy groups, tetrazolyl groups, halogen atoms, cyano groups, nitro groups, C1-6 alkyl groups, C1-6 haloalkyl groups, C3-11 cycloalkyl groups, C2-6 alkenyl groups, C2-6 haloalkenyl groups, C1-6 alkoxy groups, C1-6 haloalkoxy groups, C1-6 alkylthio groups, C1-6 haloalkylthio groups, C1-6 alkylcarbonyl groups, C1-6 haloalkylcarbonyl groups, C1-6 alkylsulfonyl groups, C1-6 haloalkylsulfonyl groups, C1-6 alkoxycarbonyl groups, 3 to 11-membered non-aromatic heterocyclyl groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, mono-C1-6 alkylaminocarbonyl groups, di-C1-6 alkylaminocarbonyl groups and C1-6 alkylcarbonylamino groups,
• the substituent set V2b consists of the groups in the substituent set V1b, and C6-14 aryl groups and 5 to 10-membered aromatic heterocyclyl groups (the C6-14 aryl groups and the 5 to 10-membered aromatic heterocyclyl groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V1b),
• the substituent set V3b consists of hydroxy groups, amino groups, carboxy groups, carbamoyl groups, sulfamoyl groups, phosphono groups, phosphonooxy groups, sulfo groups, sulfoxy groups, tetrazolyl groups, halogen atoms, cyano groups, nitro groups, C1-6 alkoxy groups, C1-6 haloalkoxy groups, C1-6 alkylthio groups, C1-6 haloalkylthio groups, C1-6 alkylcarbonyl groups, C1-6 haloalkylcarbonyl groups, C1-6 alkylsulfonyl groups, C1-6 haloalkylsulfonyl groups, C1-6 alkoxycarbonyl groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, mono-C1-6 alkylaminocarbonyl groups, di-C1-6 alkylaminocarbonyl groups, C1-6 alkylcarbonylamino groups, C3-11 cycloalkyl groups, 3 to 11-membered non-aromatic heterocyclyl groups, C6-14 aryl group and 5 to 10-membered aromatic heterocyclyl groups (the C3-11 cycloalkyl groups, the 3 to 11-membered non-aromatic heterocyclyl groups, the C6-14 aryl groups and the 5 to 10-membered aromatic heterocyclyl groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V1b),
• the substituent set V4b consists of hydroxy groups, amino groups, carboxy groups, carbamoyl groups, sulfamoyl groups, phosphono groups, phosphonooxy groups, sulfo groups, sulfoxy groups, tetrazolyl groups, halogen atoms, cyano groups, nitro groups, C1-6 alkyl groups, C2-6 alkenyl groups, C1-6 alkoxy groups, C1-6 alkylthio groups, C1-6 alkylcarbonyl groups, C1-6 alkylsulfonyl groups, C1-6 alkoxycarbonyl groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, mono-C1-6 alkylaminocarbonyl groups, di-C1-6 alkylaminocarbonyl groups, C1-6 alkylcarbonylamino groups (the C1-6 alkyl groups, the C2-6 alkenyl groups, the C1-6 alkoxy groups, the C1-6 alkylthio groups, the C1-6 alkylcarbonyl groups, the C1-6 alkylsulfonyl groups, the C1-6 alkoxycarbonyl groups, the mono-C1-6 alkylamino groups, the di-C1-6 alkylamino groups, the mono-C1-6 alkylaminocarbonyl groups, the di-C1-6 alkylaminocarbonyl groups and the C1-6 alkylcarbonylamino groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b), C3-11 cycloalkyl groups, 3 to 11-membered non-aromatic heterocyclyl groups, C6-14 aryl groups and 5 to 10-membered aromatic heterocyclyl groups (the C3-11 cycloalkyl groups, the 3 to 11-membered non-aromatic heterocyclyl groups, the C6-14 aryl groups and the 5 to 10-membered aromatic heterocyclyl groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V1b),
• the substituent set V5b consists of hydroxy groups, amino groups, carboxy groups, carbamoyl groups, sulfamoyl groups, phosphono groups, phosphonooxy groups, sulfo groups, sulfoxy groups, tetrazolyl groups, halogen atoms, cyano groups, nitro groups, C1-6 alkoxy groups, C1-6 alkylthio groups, C1-6 alkylcarbonyl groups, C1-6 alkylsulfonyl groups, C1-6 alkoxycarbonyl groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, mono-C1-6 alkylaminocarbonyl groups, di-C1-6 alkylaminocarbonyl groups, C1-6 alkylcarbonylamino groups, C3-11 cycloalkyl groups, 3 to 11-membered non-aromatic heterocyclyl groups, C6-14 aryl groups and 5 to 10-membered aromatic heterocyclyl groups (the C1-6 alkoxy groups, the C1-6 alkylthio groups, the C1-6 alkylcarbonyl groups, the C1-6 alkylsulfonyl groups, the C1-6 alkoxycarbonyl groups, the mono-C1-6 alkylamino groups, the di-C1-6 alkylamino groups, the mono-C1-6 alkylaminocarbonyl groups, the di-C1-6 alkylaminocarbonyl groups, the C1-6 alkylcarbonylamino groups, the C3-11 cycloalkyl groups, the 3 to 11-membered non-aromatic heterocyclyl groups, the C6-14 aryl groups and the 5 to 10-membered aromatic heterocyclyl groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b),
• the substituent set V6b consists of hydroxy groups, amino groups, carboxy groups, carbamoyl groups, sulfamoyl groups, phosphono groups, phosphonooxy groups, sulfo groups, sulfoxy groups, tetrazolyl groups, halogen atoms, cyano groups, nitro groups, C1-6 alkoxy groups, C1-6 alkylthio groups, C1-6 alkylcarbonyl groups, C1-6 alkylsulfonyl groups, C1-6 alkoxycarbonyl groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, mono-C1-6 alkylaminocarbonyl groups, di-C1-6 alkylaminocarbonyl groups, C1-6 alkylcarbonylamino groups (the C1-6 alkoxy groups, the C1-6 alkylthio groups, the C1-6 alkylcarbonyl groups, the C1-6 alkylsulfonyl groups, the C1-6 alkoxycarbonyl groups, the mono-C1-6 alkylamino groups, the di-C1-6 alkylamino groups, the mono-C1-6 alkylaminocarbonyl groups, the di-C1-6 alkylaminocarbonyl groups and the C1-6 alkylcarbonylamino groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b), C3-11 cycloalkyl groups, 3 to 11-membered non-aromatic heterocyclyl groups, C6-14 aryl groups, 5 to 10-membered aromatic heterocyclyl groups, 8 to 14-membered partially saturated aromatic cyclic groups and 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon groups (the C3-11 cycloalkyl groups, the 3 to 11-membered non-aromatic heterocyclyl groups, the C6-14 aryl groups, the 5 to 10-membered aromatic heterocyclyl groups, the 8 to 14-membered partially saturated aromatic cyclic groups and the 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V4b and the substituent set V9b), and
• the substituent set V8b consists of 8 to 14-membered partially saturated aromatic cyclic groups and 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon groups (the 8 to 14-membered partially saturated aromatic cyclic groups and the 8 to 14-membered aromatic ring-condensed alicyclic hydrocarbon groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V2b),
• the substituent set V9b consists of, mono-C1-6 alkylaminosulfonyl groups, di-C1-6 alkylaminosulfonyl groups, C1-6 alkylsulfonylamino groups (the mono-C1-6 alkylaminosulfonyl groups, di-C1-6 alkylaminosulfonyl groups and C1-6 alkylsulfonylamino groups are unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V3b), C3-6 cycloalkoxy groups, C3-6 cycloalkylamino groups, C3-6 cycloalkylthio groups, C3-6 cycloalkylcarbonyl groups and C3-6 cycloalkylsulfonyl groups (the C3-6 cycloalkoxy groups, the C3-6 cycloalkylamino groups, the C3-6 cycloalkylthio groups, the C3-6 cycloalkylcarbonyl groups and the C3-6 cycloalkylsulfonyl groups unsubstituted or substituted with one or more identical or different substituents independently selected from the substituent set V2b)], a tautomer or a pharmaceutically acceptable salt of the compound or a solvate thereof.