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US 2016/0102099 A1Published application
Anti-viral compounds
AssigneeKineta, Inc.
InventorsShawn P. Iadonato, Kristin M. Bedard, Myra Wang Imanaka, Kerry W. Fowler
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
Claims20
1-26. (canceled)
A compound represented by the formula
- wherein:
- R1 and R2 are each independently H or C1-5 linear alkyl;
- R3 is H, optionally substituted C1-3 linear alkyl, optionally substituted C3-6 cycloalkyl, or optionally substituted heteroaryl;
- and
- at least one of R8, R9, R10, R11, or R12 is independently CO2Rc, OCORc, NRcRd, or CN;
- optionally, at least another one of R8, R9, R10, R11, or R12 is Rc;
- and
- Rc and Rd are independently H or C1-3 alkyl.
5 more elements
A compound represented by the formula
- wherein:
- R1 and R2 are each independently H or C1-5 linear alkyl;
- R3 is H, optionally substituted C1-3 linear alkyl, optionally substituted C3-6 cycloalkyl, or optionally substituted heteroaryl;
- R11 is CF3;
- at least one of R8, R9, R10, or R12 is independently ORc, CORc, CO2Rc, OCORc, NRcRd, CF3, CN, NO2, F, Cl, Br, or I;
- optionally, at least another one of R8, R9, R10, or R12 is Rc;
- and
- Rc and Rd are independently H or C1-3 alkyl.
5 more elements
A compound represented by the formula
- wherein:
- (i) W is a bond and R4 is H or (ii) W is S and R4 is C1-3 alkyl;
- and
- R1 and R2 are each independently H or C1-3 alkyl.
1 more element
Dependencies are inferred from the claim text.