Compositions useful for treating disorders related to kit

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• W is selected from hydrogen and
• wherein Ring A is selected from monocyclic or bicyclic aryl, monocyclic or bicyclic heteroaryl, cycloalkyl and heterocyclyl;
• each X and Y is independently selected from CR1 and N;
• Z is selected from C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, and monocyclic or bicyclic heterocyclylalkyl;
• wherein each of C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, monocyclic and bicyclic heterocyclylalkyl is independently substituted with 0-5 occurrences of RC;
• L is selected from a bond, —(C(R2)(R2))m—, —(C2-C6 alkynylene)-, —(C2-C6 alkenylene)-, —(C1-C6 haloalkylene)-, —(C1-C6 heteroalkylene)-, —(C1-C6 hydroxyalkylene)-, —C(O)—, —O—, —S—, —S(O), —S(O)2—, —N(R2)—, —O—(C1-C6 alkylene)-, alkylene)-O—, —N(R2)—C(O)—, —C(O)—N(R2)—, —(C1-C6 alkylene)-N(R2)—, —N(R2)—(C1-C6 alkylene)-, —N(R2)—C(O)—(C1-C6 alkylene)-, —C(O)—N(R2)—(C1-C6 alkylene)-, —N(R2)—S(O)2—, — S(O)2—N(R2)—, —N(R2)—S(O)2—(C1-C6 alkylene)-, and —S(O)2—N(R2)—(C1-C6 alkylene)-;
• each RA and RB is independently selected from C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclyl, halo, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 heteroalkyl, monocyclic or bicyclic aralkyl, —N(R2)(R2), cyano, and —OR2;
• each RC is independently selected from C1-C6 alkyl, C1-C6 alkynyl, halo, C1-C6 heteroalkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 hydroxyalkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aryloxy, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heterocyclyl, monocyclic or bicyclic heterocyclylalkyl, nitro, cyano, —C(O)R2, —OC(O)R2, —C(O)OR2, —SR2, —S(O)2R2, —S(O)2—N(R2)(R2), —(C1-C6 alkylene)-S(O)2—N(R2)(R2), —N(R2)(R2), —C(O)—N(R2)(R2), —N(R2)(R2)—C(O)R2, —(C1-C6 alkylene)-N(R2)—C(O)R2, —NR2S(O)2R2, —P(O)(R2)(R2), and —OR2;
• wherein each of heteroalkyl, haloalkyl, haloalkoxy, alkyl, alkynyl, cycloalkyl, aryl, aryloxy, aralkyl, heterocyclyl, heterocyclylalkyl is independently substituted with 0-5 occurrences of Ra;
• or 2 RC together with the carbon atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring substituted with 0-5 occurrences of Ra;
• each of RD and RF is independently selected from hydrogen, C1-C6 alkyl, C1-C6 cycloalkyl, hydroxyl, halo, C1-C6 alkoxy, C1-C6 haloalkyl, —N(R2)(R2), and cyano;
• each R1 is independently selected from hydrogen, C1-C6 alkyl, monocyclic aralkyl, C1-C6 hydroxyalkyl, halo, C1-C6 haloalkyl, —N(R2)(R2), and —OR2;
• each R2 is independently selected from hydrogen, hydroxyl, halo, thiol, C1-C6 thioalkyl, —NR″R″, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl, wherein each of C1-C6 alkyl, cycloalkyl and heterocyclyl is independently substituted with 0-5 occurrences of Rb, or 2 R2 together with the atoms to which they are attached form a cycloalkyl or heterocyclyl ring;
• each Ra and Rb is independently selected from hydrogen, halo, cyano, hydroxyl, C1-C6 alkoxyl, —C(O)R′, C(O)OR′, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 heteroalkyl, C1-C6 hydroxyalkyl, —NR′R′, and cycloalkyl, wherein cycloalkyl is substituted with 0-5 occurrences of R′;
• each R′ is hydrogen, hydroxyl, or C1-C6 alkyl;
• each R″ is hydrogen, C1-C6 alkyl, —C(O)—C1-C6 alkyl, —C(O)—NR′R′;
• or —C(S)—NR′R′;
• and
• m, p, and q are each independently 0, 1, 2, 3, or 4.