Compositions and methods for inhibition of the jak pathway

A compound of formula V

• or a pharmaceutically acceptable salt thereof, wherein:
• X is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halo, nitro, alkenyl, substituted alkenyl, alkynyl and substituted alkynyl;
• R is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl and substituted cycloalkyl;
• each of Z1, Z2, and Z3 independently is carbon or nitrogen, wherein if Z1 is nitrogen then Z2 and Z3 are carbon, if Z2 is nitrogen then Z1 and Z3 are carbon, and if Z3 is nitrogen then Z1 and Z2 are carbon, wherein if Z1, Z2, or Z3 is nitrogen then SO2R4R5 is not attached to the nitrogen;
• q is 0, 1, 2 or 3;
• each R3 independently is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, cycloalkyl or substituted cycloalkyl, halo, heterocyclic and substituted heterocyclic;
• R4 and R5 independently are selected from the group consisting of hydrogen, alkyl, substituted alkyl, acyl and M+, wherein M+ is a metal counterion selected from the group consisting of K+, Na+, Li+ or +N(R6)4, wherein R6 is hydrogen or alkyl, and the nitrogen of SO2NR4R5 is N−;
• or
• R4 or R5 is a divalent counterion selected from the group consisting of Ca2+, Mg2+, and Ba2+, and the nitrogen of SO2NR4R5 is N−;
• or
• R4 and R5 together with the nitrogen atom bound thereto, form a heterocyclic or substituted heterocyclic group;
• R7 is selected from the group consisting of hydrogen, alkyl or substituted alkyl;
• and
• V is selected from the group consisting of C1-C3 alkylene, substituted C1-C3 alkylene, C2-C3 alkenylene and substituted C2-C3 alkenylene, wherein one or more of the carbon atoms have been replaced with a heteroatom selected from oxygen, sulfur, S(O), S(O)2, or NR8, where R8 is selected from the group consisting of hydrogen and alkyl, or is a bond participating in a —N═C< site of unsaturation.