Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(s)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide
AssigneeSanofi
InventorsLaurent Lafferrere, Sebastien Villion, Sandrine Gauthier, Andre Bourbon
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Abstract
The invention relates to the tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl) -benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide, to its crystalline form, to its preparation and to its therapeutic use.
Claims10
An L-tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide.
A process for the preparation of an L-tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide, comprising reacting a free base form of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide with L-tartaric acid in a solvent.
(canceled)
A pharmaceutical composition comprising an L-tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propyl]amide and at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.