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US 2016/0102072 A1Published application
Fungicidal compositions
AssigneeViamet Pharmaceuticals, Inc.
InventorsWilliam Hoekstra, Michael R. Loso, Gary D. Gustafson, Daniel Knueppel, Zachary A. Buchan, Michael T. Sullenberger
Life of this patent
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Abstract
The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Claims23
A compound of Formula I, or salt, solvate, hydrate or prodrug thereof, wherein:
- MBG is
- R1 is H, alkyl, haloalkyl, cycloalkyl, benzyl, or (heteroaryl)alkyl;
- R2 is halo, aryl, heteroaryl, aryloxy, alkoxy, haloalkoxy, heteoaryloxy, alkyl, cycloalkyl, cycloalkoxy, halocycloalkoxy, haloalkyl, (alkoxy)alkyl, (haloalkoxy)alkyl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, or (heteroaryl)alkyl wherein each of the aryls and heteroaryls can independently be substituted with 1, 2 or 3 groups from R4;
- R3 is aryl, heteroaryl, alkyl or cycloalkyl optionally substituted with 0, 1, 2 or 3 independent R4;
- and
- R4 is independently halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, NO2, CN, alkoxy, haloalkoxy, or thioamide ((C═S)NH2).
3 more elements
-20. (canceled)
-38. (canceled)
(canceled)
(canceled)
-49. (canceled)
A compound of Formula II wherein:
- R5 is halo, aryl, heteroaryl, aryloxy, alkoxy, haloalkoxy, heteoaryloxy, alkyl, cycloalkyl, cycloalkoxy, halocycloalkoxy, haloalkyl, (alkoxy)alkyl, (haloalkoxy)alkyl, (aryl)alkyl, (aryl)alkenyl, (aryl)alkynyl, or (heteroaryl)alkyl wherein each of the aryls and heteroaryls can independently be substituted with 1, 2 or 3 groups from R6;
- and
- R6 is independently halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, NO2, CN, alkoxy, haloalkoxy, or thioamide ((C═S)NH2);
- with the proviso that R5 cannot be
1 more element
Dependencies are inferred from the claim text.