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US 2016/0102067 A1Published application
Oxiran amines
AssigneeV-Biotek Holding Aps
InventorJens Steen OLSEN
Life of this patent
Estimating the term…
Abstract
Disclosed herein are oxiran amines useful for the treatment of a variety of diseases. The oxiran amines are useful in the manufacture of pharmaceutical compositions. The pharmaceutical composition may be used for the treatment or prevention of a disease caused by a virus having a lipid membrane or the pharmaceutical composition may be used for diseases requiring cell proliferation or immune-regulation.
Claims22
A compound of the general formula:
- wherein
- X represents O or S,
- R1 independently represents hydrogen;
- a straight or branched alkyl, alkenyl or alkynyl group containing up to 6 carbon atoms, optionally substituted by one or more halogen atoms or one or more groups R5;
- or a cycloalkyl or cycloalken group containing from 3 to 7 carbon atoms, said group optionally being substituted by one or more groups R5 or one or more halogen atoms,
- R2 represents a straight or branched alkyl, alkenyl or alkynyl group containing 3 to 24 carbon atoms, said group optionally being substituted by one or more halogen atoms, a cycloalkyl group containing from 3 to 6 carbon atoms, or one or more groups R5,
- R3 and R4 may independently represent hydrogen, a straight or branched alkyl, alkenyl or alkynyl group containing up to six carbon atoms, said group optionally being substituted by one or more halogen atoms, or may together with the nitrogen atom to which they are joined or together with R1 form 5 to 7 membered saturated or unsaturated heterocyclic ring containing up to three ring heteroatoms selected from nitrogen, oxygen and sulfur, which ring is optionally substituted by one or more groups selected from halogen, nitro, —S(O)pR6, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, ═O, and ═NO-R5, it being understood that a sulphur atom, where present in the ring, may be in the form of a group —SO2— or —SO—;
- R5 represents a straight or branched alkyl group containing up to six carbon atoms, said group optionally being substituted by one or more halogen atoms, a C1-4 alkoxy, or a straight or branched alkenyl or alkynyl group containing from 2 to 6 carbon atoms, said group optionally being substituted by one or more halogen atoms;
- and
- R6 represents a straight or branched alkyl group containing up to six carbon atoms, said group optionally being substituted by one or more halogen atoms;
- p is 0, 1, or 3
- and pharmaceutically acceptable salts thereof.
9 more elements
Dependencies are inferred from the claim text.