US 2016/0102065 A1 · NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF

Abstract

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Claims34

Dependent claims

A compound represented by Formula 1 below:

wherein R1 to R4 are identical to or different from each other, and are any one of H, OH, a C1 to C4 alkoxy, halogen, acetoxy, and benzyloxy. X is any one of H, phenyl, and C1 to C4 alkyl, and A is any one of an aromatic ring and a heterocyclic ring, and is any one of thiazolidine-2,4-dione, pyrimidine-2,4,6(1H,3H,5H)-trione, imidazolidine-2,4-dione, pyrrolidine-2,5-dione, 2-thioxodihydropyrimidine-4,6(1H,5H)-dione, 2-thioxothiazolidine-4-one, 2-imino-1-methylimidazolidine-4-one, 2-methyloxazole-5(4H)-one, 2-thioxoimidazolidine-4-one, 2-iminothiazolidine-4-one, and 2-phenyloxazole-5(4H)-one.

Dependencies are inferred from the claim text.

Facts

Application

14/973,752Filed 18 Dec 2015

Priority

KR 10-2011-00115439 Feb 2011

Published

14 Apr 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification31 codes

C07D 263/42
One oxygen atom: attached in position 5
A61K 8/49
Containing organic compounds: containing heterocyclic compounds
A61K 8/4913
With one nitrogen as the only hetero atom: having five membered rings, e.g. pyrrolidone carboxylic acid
A61K 8/4946
With more than one nitrogen as the only hetero atom: imidazoles or their condensed derivatives, e.g. benzimidazoles

Novel compound having skin-whitening, anti-oxidizing and ppar activities and medical use thereof

Life of this patent

Novel compound having skin-whitening, anti-oxidizing and ppar activities and medical use thereof

Life of this patent

Abstract

Claims34