3-aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor

A method for producing a 3-aminocarbazole compound of formula (I):

• wherein
• R1 is a halogen atom, a methyl group, a trihalomethyl group, a nitro group, a cyano group, or a triflate group, and
• R2 is a linear or branched hydroxyalkyl group having from 1 to 8 carbon atoms or a linear or branched carbonylalkyl group having from 1 to 8 carbon atoms, or
• a pharmaceutically acceptable salt thereof, a polymorphic crystal form thereof, a stereoisomer thereof, an enantiomer thereof or a prodrug thereof,
• said method comprising:
• (a) reacting an amine of formula (II):
• with a compound of formula (III):
• wherein
• Z is selected from the group consisting of Cl, Br, OH, OR, and OC(O)R, wherein R is a linear or branched alkyl having from 1 to 6 carbon atoms, to obtain a 3-aminocarbazole compound of formula (I)
• and
• (b) optionally forming a pharmaceutically acceptable salt, a polymorphic crystal form, a stereoisomer or an enantiomer of said compound of formula (I).

A method for treating or preventing an inflammatory process, pain, fever, a tumour, Alzheimer's disease, or atherosclerosis, in a mammal, comprising administering, to a subject in need thereof, a therapeutically effective amount of a 3-aminocarbazole compound of formula (I):

• wherein
• R1 is a halogen atom, a methyl group, a trihalomethyl group, a nitro group, a cyano group, or a triflate group, and
• R2 is a linear or branched hydroxyalkyl group having from 1 to 8 carbon atoms or a linear or branched carbonylalkyl group having from 1 to 8 carbon atoms, or
• a pharmaceutically acceptable salt thereof, a polymorphic crystal form thereof, a stereoisomer thereof, an enantiomer thereof or a prodrug thereof.