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US 2016/0102049 A1Published application
Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
AssigneeZach System S.P.A.
InventorsMassimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Abstract
The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.
Claims16
A process for the preparation of a compound of formula (I):
- wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain;
- said process comprising the step of reacting a compound of formula (II):
- wherein G, X and Y are as defined above with a compound of formula (III):
- wherein Z is CO or SO2 in the presence of a base,
- with the proviso that:
- i) when Z is CO the reaction is carried out at a temperature ranging from 120° C. to 180° C. and the molar ratio between the compound of formula (II) and the compound of formula (III) is from 1:10 to 1:30;
- ii) when Z is SO2, then G is —COOR2;
- to obtain a compound of formula (I).
5 more elements
Dependencies are inferred from the claim text.