Substituted n-pentanamide compounds, preparation method and the use thereof
AssigneesShanghai Institute of Materia Medica, Chinese Academy of Sciences, Topharman Shanghai Co., Ltd.
InventorsQiang ZHANG, Rongxia ZHANG, Guanghui TIAN, Jianfeng LI, Fuqiang ZHU, Xiangrui JIANG
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Abstract
The present invention relates to a (2R,3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process
Claims2
1-23. (canceled)
A compound represented by any one of the follows:
- wherein R is a protecting group of the phenolic hydroxyl.
Dependencies are inferred from the claim text.