METHOD FOR SYNTHESIZING OPTICALLY ACTIVE a-AMINO ACID USING CHIRAL METAL COMPLEX COMPRISING AXIALLY CHIRAL N-(2-ACYLARYL)-2-[5,7-DIHYDRO-6H-DIBENZO[c,e]AZEPIN-6-YL] ACETAMIDE COMPOUND AND AMINO ACID

A production method of an optically active α-amino acid or a salt thereof, the production method comprising

• introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1):
• (wherein R1 denotes hydrogen, an optionally substituted alkyl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, a halogen atom, or a nitro group;
• R2 denotes hydrogen, an optionally substituted alkyl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group;
• R3 and R4 each independently denote hydrogen, an optionally substituted alkyl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, or a halogen atom;
• the two R3s may be the same or different;
• the two R4s may be the same or different;
• R3 and R4 may form a ring together with the carbon atoms to which they are bonded;
• R5 denotes hydrogen, an optionally substituted alkyl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted alkoxy group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted carboxyl group (—CO2R7), or a halogen atom;
• the two R5s may be the same or different;
• R6 denotes hydrogen, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, or a halogen atom;
• the two R6s may be the same or different;
• the two R6s may form a ring together with the carbon atom to which they are bonded;
• R7 denotes hydrogen, an optionally substituted alkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group;
• R8 denotes hydrogen, an optionally substituted alkyl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, or an optionally substituted heteroarylalkyl group;
• * denotes a chiral axis;
• and
• M denotes a divalent metallic cation)
• by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction;
• and
• releasing the substituent-introduced α-amino acid or a salt thereof by acid decomposition.