US 2016/0101290 A1 · SYSTEM AND METHODS FOR IMPROVING DEVICE THERAPY USING MULTIPLE SENSOR METRICS

Abstract

Devices and methods for improving device therapy such as cardiac resynchronization therapy (CRT) by determining a desired value for a device parameter are described. An ambulatory medical device can receive one or more physiologic signals and generate multiple signal metrics from the physiologic signals. The ambulatory medical device can determine a desired value for a device parameter, such as a timing parameter used for controlling the delivery of CRT pacing to various heart chambers, using information fusion of signal metrics that are selected based on one or more of a signal metric sensitivity to perturbations to the device parameter in response to a stimulation, a signal metric variability in response to a stimulation, or a covariability between two or more signal metrics in response to a stimulation. The ambulatory medical device can program a stimulation using the desired device parameter value, and deliver the programmed stimulation to one or more target sites to achieve desired therapeutic effects.

Claims20

Dependent claims

A system, comprising:

a signal sensor circuit coupled to one or more physiologic sensors, the signal sensor circuit configured to sense one or more physiological signals and generate two or more signal metrics from the one or more physiologic signals;
a stimulator circuit configured to generate and deliver electrostimulation to a heart;
a controller circuit coupled to the signal sensor circuit and the stimulator circuit, the controller circuit configured to:
program the stimulator circuit to generate and deliver electrostimulation according to a device parameter programmed to a specified value;
configure the signal sensor circuit to sense the one or more physiological signals during the electrostimulation and generate the two or more signal metrics;
and
determine a desired value of the device parameter using one or more of respective sensitivity of the two or more signal metrics, respective variability of the two or more signal metrics, or a covariability between the two or more signal metrics, wherein the sensitivity of a respective signal metric is determined using a comparison of values of the same signal metric during stimulation sessions according to the device parameter programmed to different values.

4 more elements

Dependencies are inferred from the claim text.

System and methods for improving device therapy using multiple sensor metrics

Life of this patent

System and methods for improving device therapy using multiple sensor metrics

Life of this patent

Abstract

Claims20