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US 2016/0101222 A1Published application
Method of treating with poly(l-lactide) stent with tunable degradation rate
AssigneeAbbott Cardiovascular Systems Inc.
InventorsYunbing Wang, Xiao Ma
Life of this patent
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Abstract
Methods of treating with a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.
Claims13
(canceled)
A method of treating atherosclerotic stenosis in a blood vessel, comprising:
- deploying a bioabsorbable polymeric stent at a stenotic section of a blood vessel in a human body, the stent including a scaffolding composed of a pattern of struts,
- wherein the scaffolding comprises poly(L-lactide) and between 0.05 to 0.5 wt % L-lactide monomer mixed, dispersed, or dissolved within the poly(L-lactide), the scaffolding comprising greater than 95 wt % poly(L-lactide) and a crystallinity of the scaffolding is between 20-50%,
- wherein the stent has a radial strength sufficient to maintain the section of the blood vessel at a diameter at least 50% of a diameter of the deployment for a period of support and during the period of support, the blood vessel is positively remodeled,
- wherein the radial strength decreases and a load of the blood vessel is gradually transferred to the vessel wall of the positively remodeled blood vessel,
- wherein mechanical integrity of the scaffolding starts to be lost when fractures appear or propagate in the struts which is followed by breaking or loss of connectivity of the struts and complete absorption of the scaffolding into the human body.
2 more elements
Dependencies are inferred from the claim text.