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US 2016/0101220 A1Published application
Coatings containing multiple drugs
AssigneeMicell Technologies, Inc.
InventorsJames P. DeYoung, Charles Douglas Taylor, James B. McClain, Clint Smoke, Mike Cole
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Abstract
A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
Claims41
A method of depositing a coating on a substrate comprising:
- a. providing a substrate;
- b. depositing at least one polymer layer in dry powder form onto said substrate;
- c. depositing at least one pharmaceutical layer comprising a pharmaceutical agent onto said substrate without use of a solvent;
- and
- d. sintering said at least one polymer layer so as to produce a polymer film fused and adhered to said substrate under conditions that do not substantially modify a morphology of said pharmaceutical agent,
- wherein said pharmaceutical agent comprises a morphology that is crystalline or semi-crystalline.
3 more elements
A coated substrate comprising
- a. a substrate;
- and
- b. at least one polymer layer;
- c. a pharmaceutical layer comprising at least one pharmaceutical agent;
- wherein said at least one polymer layer comprises a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been substantially modified and said first pharmaceutical agent is crystalline or semi-crystalline.
2 more elements
Dependencies are inferred from the claim text.