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AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsMichael B. Chancellor, Johnny Huard, Christopher C. Capelli, Steve Chung, Michael S. Sacks
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A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications. The stem cells can be from numerous sources and may be homogeneous, heterogeneous, autologous, and/or allogeneic in the matrix material. The stem cell-matrix compositions provide point of service utility for the practitioner, wherein the stem cells and matrix can be combined not long before use, thereby alleviating costly and lengthy manufacturing procedures. In addition, the stem cells offer unique structural properties to the matrix composition which improves outcome and healing after use. Use of stem cells obtained from muscle affords contractility to the matrix composition.
A method of repairing and/or patching a blood vessel comprising seeding a single layer of small intestine submucosa (SIS) with muscle-derived progenitor cells (MSC) to form a MSC/SIS matrix;
A method of repairing urethral muscle in a subject in need thereof comprising:
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