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US 2016/0101200 A1Published application
Methods for sterilizing compositions and resulting compositions
AssigneeAllergan, Inc.
InventorsKaustubh S. Chitre, Xiaojie Yu, Nicolas J. Manesis
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Abstract
Method for sterilizing a hydrogel composition include subjecting the composition to pulsed light comprising broadband spectrum radiation, the pulsed light being at a dose effective to sterilize the composition without causing significant change in rheology of the composition.
Claims55
An injectable composition for use in fat grafting procedures, the composition comprising:
- (a) a sterile hydrogel product comprising hyaluronic acid crosslinked to collagen;
- the product having been sterilized by exposure to pulsed light comprising broadband spectrum radiation having a band range from about 100 nm to about 1100 nm wavelength, wherein the pulsed light is effective to sterilize the product without causing significant deterioration of the product;
- (b) adipose tissue.
A procedure comprising:
- providing a hydrogel comprising hyaluronic acid crosslinked with collagen;
- subjecting the hydrogel to pulsed light, thereby providing a sterile hydrogel product;
- combining the sterile hydrogel product with adipose tissue to produce a combination product;
- and
- injecting the combination product into a human patient to augment or reconstruct human soft tissue;
- wherein the pulsed light comprises broadband spectrum radiation having a band range from about 100 nm to about 1100 nm wavelength;
- and wherein the pulsed light is effective to sterilize the hydrogel without causing significant deterioration of the hydrogel.
4 more elements
Dependencies are inferred from the claim text.