Method of diagnosing and treating alzheimer's disease
AssigneeNeuroSn, Inc.
InventorsGilbert R. Gonzales, Nigel R. Stevenson
Life of this patent
Estimating the term…
Abstract
Alzheimer's disease is treated by attacking hyperactive microglia preferably before excessive beta amyloid is built up by administering tin-117m-DOTA annexin V. This compound in low radioactive doses selectively binds to the aged hyperactive microglia and emits a conversion electron which effectively induces apoptosis in the hyperactive microglia. A follow-up treatment of tin-annexin A1 can be administered to repair the blood brain barrier. The annexin A1 assists in the repair of the blood-brain barrier and the associated tin-117m will induce apoptosis in aged hyperactive microglia associated with the blood brain barrier.
Claims21
A method of treating Alzheimer's disease comprising administering to an individual having Alzheimer's disease an amount of tin-117m annexin effective to induce apoptosis in aged hyperactive microglia cells in the brain.
A method of detecting hyperactive microglia comprising administering to an individual annexin V labeled with a detectable radionuclide and noninvasively detecting said radionuclide in a brain of said patient.
A composition comprising tin-117m-annexin A1.
Dependencies are inferred from the claim text.