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AssigneeNovartis AG
InventorsFrancesco BERTI, Giulia BROGIONI, Paolo COSTANTINO, Giuseppe DEL GIUDICE, Maria ROMANO
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This specification is directed to nonlinear saccharide conjugates that comprise polysaccharides that are linked to at least two peptides that comprise T-cell epitopes and have no conformational B-cell epitopes where one of the peptides is linked to an internal saccharide so that the conjugates have a branched (i.e., nonlinear) structure. The specification also provides methods of manufacturing these conjugates, methods of formulating these conjugates in compositions for use as vaccines and methods of using the compositions to induce an immune response to the capsular saccharide. The specification also provides a new polyepitope carrier peptide comprising the PV1 epitope from polio virus. The new polyepitope carrier peptide can be used in both linear saccharide conjugates as well as the nonlinear saccharide conjugates.
A composition comprising a nonlinear saccharide conjugate that comprises a saccharide selected from a polysaccharide and an oligosaccharide, wherein the saccharide is linked to at least two carrier peptides, wherein the at least two carrier peptides comprise at least one T-cell epitope and have no conformational B-cell epitopes and wherein at least one of the at least two peptides is internally linked to the saccharide.
A composition comprising a saccharide conjugate that comprises a saccharide selected from a polysaccharide and an oligosaccharide, wherein the saccharide linked to a peptide comprises at least two T-cell epitopes having no conformational B-cell epitopes and wherein at least one of the T-cell epitopes is the PV1 epitope.
Dependencies are inferred from the claim text.