Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
AssigneeFoamix Pharmaceuticals Ltd.
InventorsDov Tamarkin, Elana Gazal, Irakliy Papiashvili, Yohan Hazot, David Schuz, Rita Keynan
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Abstract
A substantially surface active agent tree composition which includes a hydrophobic solvent, and/or a petrolatm, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent tree composition.
Claims31
(canceled)
A method for the treatment, alleviation, or prophylaxis of a disorder of the skin or mucosa comprising topically applying on at least alternate days or at least once daily to a target area on the skin or mucosa of a subject having the disorder, a hydrophobic gel or foam composition essentially free of pharmaceutically active agents, comprising
- a) about 60% to about 95% by weight of the composition of at least one hydrophobic solvent;
- and
- b) (i) a wax;
- and
- (ii) a fatty alcohol, a fatty acid, or both;
- wherein the wax comprises a hydrogenated castor oil, a beeswax, or both;
- wherein the composition is waterless;
- wherein if the gel is packaged in a canister with an outlet valve to which is added a liquefied or compressed gas propellant, the composition affords upon release from the canister a breakable hydrophobic foam from the hydrophobic gel composition.
A method for the treatment, alleviation, or prophylaxis of a disorder of the skin or mucosa comprising topically applying on at least alternate days or at least once daily to a target area on the skin or mucosa of a subject having the disorder, a hydrophobic gel or foam composition essentially free of pharmaceutically active agents, comprising
- a) about 75.5% to about 88% by weight of the composition of at least one hydrophobic solvent;
- and
- b) (i) a wax;
- (ii) a fatty alcohol, a fatty acid, or both;
- and
- (iii) a color agent
- wherein the wax is about 2% to about 6% by weight of the composition and comprises a hydrogenated castor oil, a beeswax, or both;
- wherein the fatty alcohol is about 6.5% to about 10.5% by weight of the composition and comprises one or more of myristyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol and behenyl alcohol;
- wherein the fatty acid comprises stearic acid and is about 2% to about 4% by weight of the composition;
- wherein the composition is free of water;
- wherein the disorder is selected from the group consisting of acne, acne conglobate, acne fulminans, acne vulgaris, nodular papulopustar acne, atopic dermatitis, contact dermatitis, perioral dermatitis, psoriasis, neurodermitis, and any two or more thereof, and
- wherein if the gel is packaged in a canister with an outlet valve to which is added a liquefied or compressed gas propellant the composition affords upon release from the canister a breakable hydrophobic foam from the hydrophobic gel composition.
Dependencies are inferred from the claim text.