Aqueous ophthalmic suspension of crystalline rebamipide
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsTakakuni MATSUDA, Shogo HIRAOKA, Yuso TOMOHIRA, Shinichi ISHIKAWA
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Abstract
The invention provides an ophthalmic product containing rebamipide, which has a transparency enough to be agreeable feeling on using it and has neutral so weakly acidic pH not to injury of the keratoconjunctiva of a patient suffering from dry eye. An aqueous suspension of crystalline rebamipide which has an improved transparency is provided by adding an aqueous solution of rebamipide dissolved by a base such as sodium hydroxide or an aqueous solution of a salt of rebamipide to an aqueous acidic solution such as hydrochloric acid containing at least one of the compounds selected from water-soluble polymers and surfactants, and mixing them.
Claims3
A method of preparing an aqueous suspension of crystalline rebamipide, comprising mixing at least one of the compounds selected from water-soluble polymers and surfactants, an aqueous acidic solution, and an aqueous solution containing a water-soluble salt of rebamipide,
- wherein the shape of the crystalline rebamipide is a regular needle crystal having a long gage length of less than 1000 nm and a short gage length of less than 60 nm, provided that the ratio between the long gage length and the short gage length is not less than 4.
Dependencies are inferred from the claim text.