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US 2016/0101177 A1Published application
pH AND LIGHT ACTIVATED ANTI-CANCER DRUGS
AssigneeThe Board of Trustees of The University of Alabama
InventorsElizabeth T. Papish, Jared J. Paul, Edward J. Merino
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Abstract
Described are compositions of metal complexes that can be selectively activated by light when the metal complex is under acidic conditions, such as in a cancer cell. In some aspects, the metal complex can be utilized in a drug formulation with anti-cancer activity.
Claims19
A metal complex, comprising:
- at least one metal atom and at least one ligand, wherein the ligand disassociates from the metal atom when the metal complex is contacted with light and is at a pH below 7.
A metal complex having Formula I:
- where M is a metal, X1 and X2 are protic groups, and each L is either a monodentate ligand or together with another L a bidentate ligand.
Dependencies are inferred from the claim text.