Polymeric hydrogel pharmaceutical compositions with on-demand release of a drug in response to a electrical stimulus
AssigneeUniversity of the Witwatersrand, Johannesburg
InventorsViness PILLAY, Sunaina INDERMUN, Lisa Claire DU TOIT, Yahya Essop CHOONARA,, Pradeep KUMAR
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Abstract
A polymeric hydrogel pharmaceutical dosage form for drug delivery to a target site of a human or animal. The dosage form includes polyethylene-imine (PEI) and 1-vinylimidazole (1VA), the dosage form being electro-responsive in use. Also, methods of manufacturing the dosage form and methods of treating chronic pain utilizing the dosage form.
Claims19
A polymeric hydrogel pharmaceutical dosage form for drug delivery to a target site of a human or animal, the dosage form comprising:
- polyethyleneimine (PEI) and 1-vinylimidazole (1VA) forming an electro responsive matrix,
- wherein application of an electrical stimulus to the dosage form induces a first conformational change in the dosage form resulting in a release conformation which facilitates an increase in the release rate of the drug from the dosage form to the target site, and
- wherein cessation of the electrical stimulus to the dosage form induces a second conformational change in the dosage form resulting in a drug containing conformation which facilitates a decrease in the release rate of the drug from the dosage form to the target site.
15-26. (canceled)
A method of manufacturing a polymeric hydrogel pharmaceutical dosage form for drug delivery to a target site of a human or animal, the method comprising the following step(s):
- preparing a polyvinyl alcohol (PVA) solution to which polyethyleneimine (PEI) and 1-vinylimidazole (1VA) is added to form a first mixture;
- adding a drug, acrylic acid and a crosslinking agent to the first mixture;
- and
- allowing a hydrogel to form which contains the drug and is responsive to electrical stimulus.
Dependencies are inferred from the claim text.