Immunization to protect against adverse cardiac events relating to pneumococcal infection
AssigneeBoard of Regents, The University of Texas System
InventorsCarlos J. ORIHUELA, Elaine I. TUOMANEN, Armand O. BROWN
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Abstract
In some aspects, provided herein are methods and compositions for treating or preventing adverse cardiac events in a patient who has suffered an invasive pneumococcal infection or is at risk of such an infection. The compositions include fusion proteins comprising a CbpA polypeptide or active fragment or variant thereof and optionally a T cell epitope (TCE) and a third immunogenic polypeptide from a bacteria.
Claims31
A method of preventing adverse cardiac events in a patient comprising administering an effective amount of a composition to a patient, wherein the composition comprises an immunogenic polypeptide from a bacteria, wherein the patient has been identified as being at risk for developing cardiac microlesions.
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Dependencies are inferred from the claim text.