Compositions and methods for personalized neoplasia vaccines
AssigneesThe Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation
InventorsNir Hacohen, Catherine Ju-Ying Wu, Edward F. Fritsch
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Abstract
The invention provides a method of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia, which includes identifying a plurality of mutations in the neoplasia, analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof, and producing, based on the identified subset, a personalized neoplasia vaccine.
Claims39
A method of making a personalized neoplasia vaccine for a subject diagnosed as having a neoplasia, comprising:
- identifying a plurality of mutations in the neoplasia;
- analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof;
- and
- producing, based on the identified subset, a personalized neoplasia vaccine.
A method of treating a subject diagnosed as having a neoplasia with a personalized neoplasia vaccine, comprising:
- identifying a plurality of mutations in the neoplasia;
- analyzing the plurality of mutations to identify a subset of at least five neo-antigenic mutations predicted to encode expressed neo-antigenic peptides, the neo-antigenic mutations selected from the group consisting of missense mutations, neoORF mutations, and any combination thereof;
- producing, based on the identified subset, a personalized neoplasia vaccine;
- and
- administering the personalized neoplasia vaccine to the subject, thereby treating the neoplasia.
Dependencies are inferred from the claim text.