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US 2016/0101168 A1Published application
Attenuated salmonella bacteria and methods of using
AssigneeCity of Hope
InventorsMohamed I. HUSSEINY ELSAYED, Kevin FERRERI
Life of this patent
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Abstract
Provided herein are attenuated Salmonella bacteria for expressing autoantigen alone or in combination with an immunomodulator, as well as methods of using these bacteria to treat various autoimmune disorders.
Claims19
An attenuated Salmonella bacterium comprising a nucleic acid encoding a diabetic autoantigen, wherein the nucleic acid encoding the diabetic autoantigen is under the control of an SPI2 promoter.
(canceled)
A method of treating an autoimmune disorder in a subject in need thereof comprising administering:
- (a) an attenuated Salmonella bacterium comprising a nucleic acid encoding a diabetic autoantigen, wherein expression of the diabetic autoantigen is under the control of an SPI2 promoter;
- and
- (b) a vector comprising a nucleic acid encoding an immunomodulator;
- wherein administration of the attenuated Salmonella bacterium and the vector comprising a nucleic acid encoding an immunomodulator results in expression of the diabetic autoantigen and the immunomodulator in the subject.
1 more element
A method of treating an autoimmune disorder in a subject in need thereof comprising administering:
- (a) an attenuated Salmonella bacterium comprising a nucleic acid encoding a diabetic autoantigen, wherein expression of the diabetic autoantigen is under the control of an SPI2 promoter, and wherein administration of the attenuated Salmonella bacterium results in expression of the diabetic autoantigen;
- and
- (b) one or more immunomodulators.
Dependencies are inferred from the claim text.