Compositions and kits for treating pruritus and methods of using the same
AssigneeRochal Industries, LLP
InventorsJoseph Charles SALAMONE, Ann Beal SALAMONE, Kelly Xiaoyu Chen LEUNG, Katelyn Elizabeth REILLY
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Abstract
A treatment for pruritus is described that is based upon amylase. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the reduction of pruritus (itching) of affected tissue.
Claims28
An enzymatic pruritic composition for topically treating pruritus, comprising a non-proteolytic enzyme component and up to 20 wt-% of a proteolytic enzyme component, wherein said non-proteolytic enzyme component comprises at least 80% by weight of amylase, and wherein a weight ratio of non-proteolytic enzymes to proteolytic enzymes in the enzymatic pruritic composition is at least 4:1.
A method of treatment of pruritic tissue comprising
- topically administering a therapeutically effective amount of an enzymatic pruritic composition to itching tissue, wherein said enzymatic pruritic composition comprises a non-proteolytic enzyme component, said non-proteolytic enzyme component comprising at least 80% by weight of an amylase, wherein said non-proteolytic enzyme component comprises at least 10% by weight of α-amylase, based on a weight of the non-proteolytic enzyme component and wherein a ratio of non-proteolytic enzymes to proteolytic enzymes in the enzymatic pruritic composition is at least 4:1.
(canceled)
A kit, comprising:
- an enzymatic pruritic composition comprising a non-proteolytic enzyme component, wherein said non-proteolytic enzyme component comprises at least 80% by weight of amylase, and wherein a ratio of non-proteolytic enzymes to proteolytic enzymes in the enzymatic pruritic composition is at least 4:1;
- and
- instructions for topically applying said enzymatic pruritic composition to itchy tissue.
Dependencies are inferred from the claim text.