Back to results
US 2016/0101165 A1Published application
Compositions and kits for enzymatic debridement and methods of using the same
AssigneeRochal Industries, LLP
InventorsJoseph Charles SALAMONE, Kelly Xiaoyu Chen LEUNG, Ann Beal SALAMONE, Katelyn Elizabeth REILLY
Life of this patent
Estimating the term…
Abstract
A debridement enzyme for necrotic tissue is described that is not dependent upon proteolytic enzymatic activity but instead utilizes the amylase family of enzymes. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that α-amylase is effective in the debridement of devitalized tissue.
Claims28
A debridement composition comprising:
- 0.001 to 99.5 wt % of an amylase component, and
- at least one pharmaceutically or cosmetically acceptable carrier or excipient in an amount of up to 99.9 wt-%, wherein the percentages are based on a total weight of the debridement composition,
- wherein, if a proteolytic enzyme component is present, a ratio of the amylase component to the proteolytic enzyme component is at least 4:1.
(canceled)
Dependencies are inferred from the claim text.