Peptide for inhibition of binding between angiopoietin-2 and integrin and use thereof
AssigneeSamsung Electronics Co., Ltd.
InventorsSang Yeul Han, Chung Ho Kim, Kyung Eun Kim, Hyung-Chan Kim, Kwang-Hoon Lee, Hyo Seon Lee
Life of this patent
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Abstract
Angiopoietin-2 (Ang2) derived peptides, polypeptides, and peptide complexes, and a method for inhibition of binding between Ang2 and integrin and prevention and/or treatment of a disease caused by the activation of Ang2 or the binding between Ang2 and integrin using the peptide, polypeptides, and peptide complexes.
Claims12
A method of inhibition of binding between angiopoietin-2 (Ang2) and integrin in a patient, the method comprising administering at least one peptide selected from the group consisting of:
- a peptide comprising 5 to 25 consecutive amino acids of SEQ ID NO:
- 43 including the amino acids from the 11th to 15th positions of SEQ ID NO:
- 43,
- a peptide comprising 11 to 20 consecutive amino acids of SEQ ID NO:
- 44 including amino acids from the 6th to 15th positions of SEQ ID NO:
- 44,
- a peptide comprising the amino acid sequence of SEQ ID NO:
- 24, and
- a peptide comprising the amino acid sequence of SEQ ID NO:
- 40.
A method of treating a disease in a patient caused by the activation of Ang2 or binding between Ang2 and integrin selected from the group consisting of cancer, cancer metastasis, eye disease, and inflammatory disease, the method comprising administering to the patient a therapeutically effective amount of at least one peptide selected from the group consisting of:
- a peptide comprising 5 to 25 consecutive amino acids of SEQ ID NO:
- 43 including the amino acids from the 11th to 15th positions of SEQ ID NO:
- 43,
- a peptide comprising 11 to 20 consecutive amino acids of SEQ ID NO:
- 44 including the amino acids from the 6th to 15th positions of SEQ ID NO:
- 44,
- a peptide comprising the amino acid sequence of SEQ ID NO:
- 24, and
- a peptide comprising the amino acid sequence of SEQ ID NO:
- 40.
A method of inhibition of binding between Ang2 and integrin in a patient, the method comprising administering to a patient
- (1) a polypeptide molecule comprising a first peptide and a second peptide, wherein
- (a) the first peptide inhibits the binding of Ang2 and integrin and comprises:
- (i) at least one peptide selected from the group consisting of a peptide comprising 5 to 25 consecutive amino acids of SEQ ID NO:
- 43 including the amino acids from the 11th to 15th positions of SEQ ID NO:
- 43, a peptide comprising 11 to 20 consecutive amino acids of SEQ ID NO:
- 44 including the amino acids from the 6th to 15th positions of SEQ ID NO:
- 44, a peptide comprising the amino acid sequence of SEQ ID NO:
- 24, and a peptide the amino acid sequence of SEQ ID NO:
- 40;
- or
- (ii) a peptide repeat comprising the peptide (i) repeated 2 to 20 times;
- and
- (b) the second peptide is a heavy chain or light chain of an antibody, a constant region of a heavy chain or light chain of an antibody, or an Fc fragment of an antibody;
- or
- (2) a polypeptide complex comprising 2 to 4 polypeptide molecules of (1).
A method of treatment of a disease in a patient caused by the activation of Ang2 or binding between Ang2 and integrin selected from the group consisting of cancer, cancer metastasis, eye disease, and inflammatory disease, the method comprising administering to the patient a therapeutically effective amount of:
- (1) a polypeptide molecule comprising a first peptide and a second peptide, wherein
- (a) the first peptide inhibits the binding of Ang2 and integrin and comprises:
- (i) at least one peptide selected from the group consisting of a peptide comprising 5 to 25 consecutive amino acids of SEQ ID NO:
- 43 including the amino acids from the 11th to 15th positions of SEQ ID NO:
- 43, a peptide comprising 11 to 20 consecutive amino acids of SEQ ID NO:
- 44 including the amino acids from the 6th to 15th positions of SEQ ID NO:
- 44, a peptide comprising the amino acid sequence of SEQ ID NO:
- 24, and a peptide the amino acid sequence of SEQ ID NO:
- 40;
- or
- (ii) a peptide repeat comprising the peptide (i) repeated 2 to 20 times;
- and
- (b) the second peptide is a heavy chain or light chain of an antibody, a constant region of a heavy chain or light chain of an antibody, or an Fc fragment of an antibody;
- or
- (2) a polypeptide complex comprising 2 to 4 polypeptide molecules of (1).
Dependencies are inferred from the claim text.