Compounds and methods of modulating angiogenesis
AssigneesThe Cleveland Clinic Foundation, Case Western Reserve University
InventorsTatiana Byzova, Ganapati H. Mahabaleshwar, Weiyi Feng
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition includes a synthetic peptide consisting of about 10 to about 50 amino acids and having an amino acid sequence substantially homologous to consecutive amino acids of a portion of the cytoplasmic domain of at least one of αvβ3 integrin or VEGFR2 that includes a tyrosine residue, the amino acid sequence of the peptide including a phosphorylated tyrosine residue or a γ-carboxyglutamic acid residue that is substituted for a corresponding tyrosine residue of the portion of the cytoplasmic domain of αvβ3 integrin or VEGFR2.
Claims16
1-15. (canceled)
A pharmaceutical composition comprising:
- a synthetic peptide, the peptide comprises an amino acid sequence substantially homologous to about 5 to about 30 consecutive amino acids of a portion of the cytoplasmic domain of αvβ3 integrin that includes a tyrosine residue, the amino acid of the peptide including an amino acid that structurally mimics a phosphorylated tyrosine reside that substitutes a corresponding tyrosine residue of the portion of the cytoplasmic domain of αvβ3 integrin, the peptide is about 10 to about 50 amino acids in length, and the peptide inhibits interaction of αvβ3 integrin with VEGFR2.
A pharmaceutical composition comprising:
- a synthetic peptide, the peptide comprises an amino acid sequence substantially homologous to about 5 to about 30 consecutive amino acids of a portion of the cytoplasmic domain of αvβ3 integrin that includes a tyrosine residue, the amino acid sequence of the peptide including a γ-carboxyglutamic acid residue that substitutes a corresponding tyrosine residue of the portion of the cytoplasmic domain of αvβ3 integrin, the peptide is about 10 to about 50 amino acids in length, and the peptide inhibits interaction of αvβ3 integrin with VEGFR2.
A pharmaceutical composition comprising a synthetic peptide, the peptide consisting of about 10 to about 50 amino acids and comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:23, and SEQ ID NO:
- 24.
Dependencies are inferred from the claim text.