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US 2016/0101119 A1Published application
Controlled Release Doxycycline
AssigneeMayne Pharma International Pty Ltd.
InventorsStefan Lukas, Angelo Lepore, Stuart Mudge
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Abstract
The disclosure provides controlled release compositions comprising tetracyclines and in some embodiments, doxycycline. The controlled release doxycycline compositions of the invention exhibit a superior dissolution profile and provide reduce side effects such as nausea and irritation.
Claims28
1-19. (canceled)
A dosage form comprising a plurality of modified release doxycycline pellets, wherein each doxycycline pellet comprises:
- doxycycline;
- and
- a controlled release polymer composition disposed over the doxycycline, wherein said dosage form comprises 60, 90, or 120 mg of doxycycline and maintains doxycycline release levels measured under USP <711> conditions at pH 5 that provide a clinically effective plasma level of doxycycline.
Dependencies are inferred from the claim text.