Articles and methods for preventing and treating dermatologic adverse events

An article that is juxtaposed to a patient's body, said article comprising:

• 1) an effective amount of a calcium channel blocker, vasodilator, or a pharmaceutically acceptable salt thereof;
• and
• 2) a matrix diffusion controlled system;
• wherein the matrix diffusion controlled system provides a continuous release of said calcium channel blocker, vasodilator, or a pharmaceutically acceptable salt thereof.