Pharmaceutical composition comprising n1-cyclic amine-n5-substituted biguanide derivatives as an ingredient for preventing or treating fibrosis

A method of preventing or treating fibrosis comprising administering a therapeutically effective amount of a N1-cyclic amine-N5-substituted biguanide derivative compound of Formula 1 below or a pharmaceutically acceptable salt thereof to a subject in need thereof:

• wherein R1 and R2 are taken together with nitrogen to which they are attached to form 4- to 7-membered C3-6 heterocycloalkyl or C3-6 heterocycloalkene;
• R3 is H;
• C3-7 cycloalkyl;
• C3-12 aryl;
• or C1-6 alkyl unsubstituted or substituted with C3-12 aryl or C3-12 heteroaryl;
• wherein C3-6 heterocycloalkyl, cycloalkyl, C3-12 aryl, or C3-12 heteroaryl is unsubstituted or substituted with at least one non-hydrogen substituent selected from the group consisting of halogen, C1-4 alkyl, and C1-4 alkoxy, and the non-hydrogen substituent is unsubstituted or further substituted with halogen.