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AssigneeThe Salk Institute for Biological Studies
InventorsMichael Downes, Ruth T. Yu, Vihang A. Narkar, Ronald M. Evans
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Disclosed herein are methods of improving muscular health, such as enhancing muscle regeneration, maintenance, or repair. In some examples, the method includes administering to the subject an effective amount of an agent capable of increasing activity or expression of estrogen receptor-related gamma (ERRγ), related receptors ERRα or β, or ERR-regulated metabolic and angiogenic genes, thereby enhancing muscle regeneration, maintenance, or repair. In some examples, the methods are utilized to treat a subject with one or more signs or symptoms of muscular dystrophy, such as, but not limited to Duchenne muscular dystrophy. In some examples, the disclosed methods further include selecting a subject in need of enhancing muscle regeneration, maintenance, or repair.
A method of enhancing muscle regeneration, repair, or maintenance in a subject comprising administering an effective amount of an agent that increases expression or activity of estrogen receptor-related gamma (ERRγ), related receptors ERRα or β, or ERR-regulated metabolic and angiogenic genes, thereby enhancing muscle regeneration, maintenance, or repair, thereby enhancing muscle regeneration, repair, or maintenance in a subject.
A method of treating a muscular disease or demyelinating disease, comprising:
A method for treating a muscular dystrophy, comprising:
A method of determining if an agent is useful to enhancing muscle regeneration, repair, or maintenance in a subject, comprising:
Dependencies are inferred from the claim text.