Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
AssigneeBioResponse, L.L.C.
InventorMichael A. Zeligs
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Abstract
The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.
Claims64
A method of treating or reducing the risk of a protozoal disease comprising administering to a subject in need thereof a therapeutically effective amount of one or more DIM-related indoles and one or more anti-protozoal agents.
A method of treating or reducing the risk of a protozoal disease comprising administering to a subject in need thereof a therapeutically effective amount of one or more DIM-related indoles.
A composition comprising a therapeutically effective amount of the combination of one or more DIM-related indoles and one or more anti-protozoal agents.
Wherein the anti-protozoal agent is selected from the group consisting of an extract of Yucca schidigera, a tea or extract made from Artemisia annua, a teas or extract made from Curcuma domestica, an extract from garlic, a root extract of Uvaria chamae or Hippocratea Africana, a root extract of Homalium letestui, an extract of Vernonia brasiliana, an extract of Sapindus mukorossi, and an extract from Acanthospermum australe.
Dependencies are inferred from the claim text.