Pharmaceutical combination comprising metformin and dihydroquercetin and its use for the treatment of cancer
AssigneeResearch Institute for Nutrition and Aging Co., Ltd.
InventorsKunihiko KIYONO, Kenji ONISHI, Yasuharu NAGAHAMA, Takashi WATANABE
Life of this patent
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Abstract
Provided is a novel medicament capable of reducing the side effects of metformin or a pharmaceutically acceptable salt thereof and useful as an anti-malignant tumor agent, in which metformin or a pharmaceutically acceptable salt thereof and dihydroquercetin or a pharmaceutically acceptable salt thereof are combined.
Claims15
1-27. (canceled)
A method for the prophylaxis or treatment of a malignant tumor, comprising administering metformin or a pharmaceutically acceptable salt thereof, and dihydroquercetin or a pharmaceutically acceptable salt thereof to a subject in need thereof, wherein metformin or a pharmaceutically acceptable salt thereof, and dihydroquercetin or a pharmaceutically acceptable salt thereof are administered as a single preparation or separate preparations which are administered simultaneously or at different time points.
A method of reducing the side effects of metformin or a pharmaceutically acceptable salt thereof, comprising administering dihydroquercetin or a pharmaceutically acceptable salt thereof to a patient with a malignant tumor.
A method of enhancing an anti-malignant tumor action of metformin or a pharmaceutically acceptable salt thereof, comprising administering dihydroquercetin or a pharmaceutically acceptable salt thereof.
A method of reducing the side effects of metformin or a pharmaceutically acceptable salt thereof, comprising administering dihydroquercetin or a pharmaceutically acceptable salt thereof, in combination with metformin or a pharmaceutically acceptable salt thereof, to a patient with malignant tumor.
A method of enhancing an anti-malignant tumor action, comprising administering dihydroquercetin or a pharmaceutically acceptable salt thereof, in combination with metformin or a pharmaceutically acceptable salt thereof.
A method for the prophylaxis or treatment of pancreatic cancer, comprising administering dihydroquercetin or a pharmaceutically acceptable salt thereof to a subject in need thereof.
A method of suppressing a pancreatic cancer stem cell, comprising administering dihydroquercetin or a pharmaceutically acceptable salt thereof to a subject in need thereof.
Dependencies are inferred from the claim text.