Compositions and Methods for Treating Severe Pain

A method of treating an individual with an inflammatory pain, the method comprising the step of:

• administering to the individual in need thereof a pharmaceutical composition, wherein administration results in a reduction in a symptom associated with the inflammatory pain, thereby treating the individual, and wherein the pharmaceutical composition comprises:
• a) a propionic acid derivative non-steroidal anti-pain drug (NSAID), or a pharmaceutically acceptable salt, solvate, or solvate of a salt thereof, in an amount of about 15% to about 30% of the total weight of the composition;
• b) a pharmaceutically-acceptable liquid polyethylene glycol (PEG) polymer in an amount of about 8% to about 15% of the total weight of the composition;
• and
• c) a pharmaceutically-acceptable lipid in an amount of at least 50% of the total weight of the composition, the pharmaceutically-acceptable lipid comprising a pharmaceutically-acceptable fat in an amount of at least 30% of the total weight of the composition, the pharmaceutically-acceptable fat comprising a triglyceride, an acetylated triglyceride and/or a triester of glycerol and a pharmaceutically-acceptable monoglyceride in an amount of at least 20% of the total weight of the composition,
• wherein the pharmaceutical composition is formulated to be a solid at a temperature of about 15° C. or lower and have a melting point temperature of about 25° C. or higher.