Supramolecular complexes of polyanionic polymers and spermidine in tissue maintenance and repair
AssigneeTixupharma
InventorCarlo GHISALBERTI
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Abstract
Supramolecular complexes are formed by polyanionic polymers and spermidine having a ratio of anionic equivalents ranging from 101:1 to 107:1 eq/eq, more preferably from 102:1 to 104:1 eq/eq, whose components are linked by non-covalent, ionic interactions. The supramolecular complexes are exhibit high potency in eliciting fibroblast proliferation. Disclosed are medicinal/cosmetic compositions containing the supramolecular complexes for the trophism, maintenance, regeneration, and repair of connective tissues and mucosae in damaged or senescent conditions.
Claims11
A method for the treatment of ostheoarthritis or joint damage, which comprises administering to a subject an effective amount of at least a supramolecular complex formed by at least a polyanionic polymer and spermidine with a ratio of anionic equivalents and cationic equivalents from 10:1 to 107:1 eq/eq, where the components of said supramolecular complex are intimately admixed, without any covalent bond between them.
Dependencies are inferred from the claim text.