Treatment and prevention of cardiovascular disease and thrombosis
AssigneeThe Cleveland Clinic Foundation
InventorsStanley L. Hazen, Bruce Levison, Zeneng Wang
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Abstract
Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. 20-23.
Claims20
A method for the treatment and/or prevention of cardiovascular disease and/or thrombosis comprising:
- a) identifying a subject as having increased platelet aggregation and/or elevated TMAO levels, and
- b) administering to said subject:
- i) a composition comprising a compound selected from the group consisting of:
- N,N-dimethylethanolamine (DMEA), N-methylethanolamine (MEA), ethanolamine (EA), trimethylsilyl ethanol, and P,P,P-trimethyl ethanolphosphine;
- and/or ii) a composition comprising a compound represented by Formula I:
- wherein n is an integer, or n is 0, indicating that CH2 is not present;
- wherein Y is C, Si, P, S, Ge, Sn, Pb, P, As, Sb, or Bi;
- wherein X is O or S and the corresponding bond is either present or absent or double, wherein R is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group;
- wherein Z is C, CH2, CH, O or S,
- wherein XR is an ester, thioester, or thionester;
- glycerol, or one of the following three formulas:
- wherein R′ is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group;
- and
- wherein X′ is O, or S.
A method of treating and/or preventing cardiovascular disease and/or thrombosis comprising administering to a subject:
- i) a composition comprising a compound selected from the group consisting of:
- N,N-dimethylethanolamine (DMEA), N-methylethanolamine (MEA), ethanolamine (EA), trimethylsilyl ethanol, and P,P,P-trimethyl ethanolphosphine;
- and/or ii) a composition comprising a compound represented by Formula I:
- wherein n is an integer, or n is 0, indicating that CH2 is not present;
- wherein Y is C, Si, P, S, Ge, Sn, Pb, P, As, Sb, or Bi;
- wherein X is O or S and the corresponding bond is either present or absent or double, wherein R is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group;
- wherein Z is C, CH2, CH, O or S,
- wherein XR is an ester, thioester, or thionester;
- glycerol, or one of the following three formulas:
- wherein R′ is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group;
- and
- wherein X′ is O, or S.
A food or beverage comprising:
- i) a compound selected from the group consisting of:
- N,N-dimethylethanolamine (DMEA), N-methylethanolamine (MEA), ethanolamine (EA), trimethylsilyl ethanol, and P,P,P-trimethyl ethanolphosphine;
- and/or ii) a compound represented by Formula I:
- wherein n is an integer, or n is 0, indicating that CH2 is not present;
- wherein Y is C, Si, P, S, Ge, Sn, Pb, P, As, Sb, or Bi;
- wherein X is O or S and the corresponding bond is either present or absent or double, wherein R is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group;
- wherein Z is C, CH2, CH, O or S,
- wherein XR is an ester, thioester, or thionester;
- glycerol, or one of the following three formulas:
- wherein R′ is H, an alkyl group, alkenyl group, alkynyl group, phenyl group, or a benzyl group;
- and
- wherein X′ is O, or S.
Dependencies are inferred from the claim text.